Association between time interval from neoadjuvant chemoradiotherapy to surgery and complete histological tumor response in esophageal and gastroesophageal junction cancer: a national cohort study

摘要: The optimal time interval from neoadjuvant therapy to surgery in the treatment of esophageal cancer is not known. aim this study was investigate if a prolonged between completed chemoradiotherapy and associated with improved histological response rates survival population-based national register cohort. cohort included patients treated esophagectomy due esophagus or gastroesophageal junction. Patients were divided into two groups based on median surgery. primary outcome complete response. Secondary outcomes lymph node tumor response, postoperative complications, R0 resection rate, 90-day mortality, overall survival. In total, 643 included, 344 (54%) underwent within 49 days, 299 (47%) after 50 days longer. similar concerning baseline characteristics except for higher clinical stage (P = 0.009) group. There no significant differences Adjusted odds ratio ypT0 group 0.99 (95% confidence interval: 0.64-1.53). Complete (ypT0) significantly survival: adjusted hazard ratio: 0.55 CI 0.41-0.76). If metastases present these patients, was, however, lower: ypT0N1: 2.30 1.21-4.35). prospectively collected, nationwide junctional type 1 2 there associations outcomes, results suggest that it safe postpone at least 7 10 weeks chemoradiotherapy, but evidence seen favor recommending cancer. A definitive answer question requires randomized controlled trial standard vs.