Clinical Epidemiology and the Impact of Comorbidity on Treatment and Outcome

摘要: In the beginning of twentieth century lung cancer was a very rare disease, but rates have increased so dramatically that can be considered one major epidemics century. Currently, is still number cause death among deaths. Over fifty percent all newly diagnosed patients are aged over 65 years at time diagnosis, and about 30% 70. Since disease mainly occurs in elderly smoking most important risk factor, many (smoking-related) comorbidity diagnosis. This may complicate management patients. Elderly receive standard treatment less often, although has positive effect on prognosis cancer, even after adjustment for differences age comorbidity. However, complications common, despite strict selection fittest treatment. elderly, impact toxicities quality-of-life just as prolongation life expectancy. A proper fit enough surgery, chemotherapy and/or radiotherapy therefore there an urgent need predictive models tolerance easily used everyday clinical practice.