19 F MRSI of capecitabine in the liver at 7 T using broadband transmit–receive antennas and dual-band RF pulses

作者: Jetse S. van Gorp , Peter R. Seevinck , Anna Andreychenko , Alexander J. E. Raaijmakers , Peter R. Luijten

DOI: 10.1002/NBM.3390

关键词: Fluorine-19 Magnetic Resonance ImagingMedicineNoise (electronics)In vivoImaging phantomPulse (signal processing)Palliative careRF power amplifierMagnetic resonance spectroscopic imagingNuclear magnetic resonance

摘要: Capecitabine (Cap) is an often prescribed chemotherapeutic agent, successfully used to cure some patients from cancer or reduce tumor burden for palliative care. However, the efficacy of drug limited, it not known in advance who will respond and can come with severe toxicity. (19)F Magnetic Resonance Spectroscopy (MRS) Spectroscopic Imaging (MRSI) have been non-invasively study Cap metabolism vivo find a marker personalized treatment. In detection, however, hampered by low concentrations use radiofrequency (RF) surface coils limiting spatial coverage. this work, 7T MR system radiative multi-channel transmit-receive antennas was investigated aim maximizing sensitivity coverage detection protocols. The were broadband optimized facilitate both (1)H (298 MHz) (280 MHz) frequencies accurate shimming, imaging signal combination. B1(+) simulations, phantom noise measurements showed that more than 90% theoretical maximum could be obtained when using B1(-) information provided at frequency optimization frequency. Furthermore, overcome limits available RF power, whilst ensuring simultaneous excitation all detectable conversion products Cap, dual-band pulse designed evaluated. Finally, MRS(I) performed detect metabolites vitro vivo. two patients, 10 h (patient 1) 1 h 2) after intake, detected liver surrounding organs, illustrating potential set-up metabolic rates distribution body.

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