Modeling the effects of HIV-1 virions and proteins on Fas-induced apoptosis of infected cells

摘要: We report a first in modeling and simulation of the effects HIV proteins on (caspase dependent) apoptotic pathway infected cells. This work is novel an extension recent reports clarifications FAS from literature. have gathered most reaction rates initial conditions literature, rest constants been computed by fitting our model to experimental results reported. Using obtained we then run simulations for memory T cells, called also latent which, at moment, represent major obstacle finding cure HIV. can now that cells estimated lifetime about 42 hours moment they are re-activated. As far as know this result type