Long noncoding RNAs in kidney and cardiovascular diseases
作者： Johan M. Lorenzen , Thomas Thum
关键词: MALAT1 、 Tissue homeostasis 、 Bioinformatics 、 Acute kidney injury 、 microRNA 、 Kidney 、 Human genome 、 RNA 、 Disease 、 Biology 、 Pathology
摘要: Transcription of a large part the human genome results in RNA transcripts that have limited or no protein-coding potential. These include long noncoding RNAs (lncRNAs), which are defined as being ≥200 nucleotides long. Unlike microRNAs, been extensively studied, little is known about functional role lncRNAs. However, studies over past 5 years shown lncRNAs interfere with tissue homeostasis and pathological processes, including kidney heart. The developmental expression microRNA sponge H19, for example, altered kidneys embryos carried by hyperglycaemic mothers, lncRNA Malat1 regulates hyperglycaemia-induced inflammation endothelial cells. Putative roles other identified conditions such heart failure, cardiac autophagy, hypertension, acute injury, glomerular diseases, allograft rejection renal cell carcinoma. This Review outlines our current understanding function cardiovascular disease novel important regulators potential therapeutic entry points progression.
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sci-hub.se 参考文章(77)
Yong Dai, Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis International Journal of Molecular Medicine. ,vol. 30, pp. 173- 178 ,(2012) , 10.3892/IJMM.2012.975
Gan Yu, Weimin Yao, Ji Wang, Xin Ma, Wei Xiao, Heng Li, Ding Xia, Yang Yang, Kangli Deng, Haibing Xiao, Bohan Wang, Xiaolin Guo, Wei Guan, Zhiquan Hu, Yinqi Bai, Hua Xu, Jihong Liu, Xu Zhang, Zhangqun Ye, None, LncRNAs Expression Signatures of Renal Clear Cell Carcinoma Revealed by Microarray PLoS ONE. ,vol. 7, pp. e42377- ,(2012) , 10.1371/JOURNAL.PONE.0042377
Johan M. Lorenzen, Filippo Martino, Thomas Thum, Epigenetic modifications in cardiovascular disease Basic Research in Cardiology. ,vol. 107, pp. 245- 245 ,(2012) , 10.1007/S00395-012-0245-9
Tae-Kyung Kim, Martin Hemberg, Jesse M. Gray, Allen M. Costa, Daniel M. Bear, Jing Wu, David A. Harmin, Mike Laptewicz, Kellie Barbara-Haley, Scott Kuersten, Eirene Markenscoff-Papadimitriou, Dietmar Kuhl, Haruhiko Bito, Paul F. Worley, Gabriel Kreiman, Michael E. Greenberg, Widespread transcription at neuronal activity-regulated enhancers Nature. ,vol. 465, pp. 182- 187 ,(2010) , 10.1038/NATURE09033
Hermann Koepsell, Katrin Lips, Christopher Volk, Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharmaceutical Research. ,vol. 24, pp. 1227- 1251 ,(2007) , 10.1007/S11095-007-9254-Z
A. A. Bazzini, T. G. Johnstone, R. Christiano, S. D. Mackowiak, B. Obermayer, E. S. Fleming, C. E. Vejnar, M. T. Lee, N. Rajewsky, T. C. Walther, A. J. Giraldez, Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation The EMBO Journal. ,vol. 33, pp. 981- 993 ,(2014) , 10.1002/EMBJ.201488411
Jacob Rachmilewitz, Ran Goshen, Ilana Ariel, Tamar Schneider, Nathan de Groot, Abraham Hochberg, Parental imprinting of the human H19 gene. FEBS Letters. ,vol. 309, pp. 25- 28 ,(1992) , 10.1016/0014-5793(92)80731-U
Qin Zhou, Xiao R Huang, Jianwen Yu, Xueqing Yu, Hui Y Lan, Long Noncoding RNA Arid2-IR Is a Novel Therapeutic Target for Renal Inflammation Molecular Therapy. ,vol. 23, pp. 1034- 1043 ,(2015) , 10.1038/MT.2015.31
Thomas Thum, Paolo Galuppo, Christian Wolf, Jan Fiedler, Susanne Kneitz, Linda W. van Laake, Pieter A. Doevendans, Christine L. Mummery, Jürgen Borlak, Axel Haverich, Carina Gross, Stefan Engelhardt, Georg Ertl, Johann Bauersachs, MicroRNAs in the Human Heart A Clue to Fetal Gene Reprogramming in Heart Failure Circulation. ,vol. 116, pp. 258- 267 ,(2007) , 10.1161/CIRCULATIONAHA.107.687947
Weiguo Sui, Hua Lin, Wujian Peng, Yuanshuai Huang, Jiejing Chen, Yue Zhang, Yong Dai, None, Molecular dysfunctions in acute rejection after renal transplantation revealed by integrated analysis of transcription factor, microRNA and long noncoding RNA Genomics. ,vol. 102, pp. 310- 322 ,(2013) , 10.1016/J.YGENO.2013.05.002