Immune complexes inhibit IL-1 secretion and inflammasome activation.
作者： John R. Janczy , Ceren Ciraci , Stefanie Haasken , Yoichiro Iwakura , Alicia K. Olivier
关键词: Immune receptor 、 Antibody-dependent cell-mediated cytotoxicity 、 Acquired immune system 、 Immunology 、 Immune system 、 Inflammasome 、 Immune complex 、 Biology 、 Inflammasome complex 、 Lymphokine
摘要: IgG immune complexes have been shown to modify responses driven by APCs in either a pro- or anti-inflammatory direction depending upon the context of stimulation. However, ability modulate inflammasome-dependent innate response is unknown. In this study, we show that suppress IL-1α and IL-1β secretion through inhibition inflammasome activation. The mechanism which occurs via complex ligation activating FcγRs, resulting prevention both activation assembly nucleotide-binding domain leucine-rich repeat (NLR) P3, NLRC4, AIM2 agonists. vivo, administration Ag form an during priming inhibited resultant adaptive NLRP3-dependent model allergic airway disease. Our data reveal unexpected regulating CD4 + T cell differentiation, generation from APCs, are critical for Ag-driven differentiation cells.
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