作者: Hiroki Oda , Masatoshi Takeichi
关键词: Cadherin 、 Multicellular organism 、 Biology 、 Adherens junction 、 Transmembrane protein 、 Protein structure 、 Cell adhesion 、 Adhesion 、 Morphogenesis 、 Cell biology
摘要: Adhesion between cells is essential to the evolution of multicellularity. Indeed, morphogenesis in animals requires firm but flexible intercellular adhesions that are mediated by subcellular structures like adherens junction (AJ). A key component AJs classical cadherins, a group transmembrane proteins maintain dynamic cell–cell associations many animal species. An evolutionary reconstruction cadherin structure and function provides comprehensive framework with which appreciate diversity morphogenetic mechanisms animals.