Iron overload in Chinese patients with hemoglobin H disease.
作者： Hui-Chi Hsu , Chung-King Lin , Shyh-Haw Tsay , Elizabeth Tse , Chao-Hung Ho
关键词: Hemochromatosis 、 Gastroenterology 、 Hemosiderosis 、 Pathology 、 Liver biopsy 、 Internal medicine 、 Transferrin saturation 、 Medicine 、 Hemoglobin H Disease 、 Hemoglobinopathy 、 Ferritin 、 Serum iron
摘要: We examined the iron status of 23 adult patients with hemoglobin H (Hb H) disease. None them had received multiple blood transfusions or prolonged therapy. Studies included serum and ferritin concentrations, transferrin saturation, a desferrioxamine test, computed tomography (CT) scan liver, liver biopsy. Iron overload was found in 17 (73.9%), especially males splenomegaly (92.9% 100%, respectively). Four excessive alcohol consumption clinical manifestations severe overload. Idiopathic hemochromatosis associated HLA antigens, i.e., HLA-A3, -B7, -B14, were not any 15 tested. These findings indicate that is common Hb disease; such should abstain from be considered for treatment an chelating agent before irreversible organ damage occurs.
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