Lack of pre-synaptic dopaminergic involvement in modafinil activity in anaesthetized mice: in vivo voltammetry studies.
作者： J.E. De Séréville , C. Boer , F.A. Rambert , J. Duteil
DOI: 10.1016/0028-3908(94)90115-5
关键词: Modafinil 、 Caudate nucleus 、 In vivo 、 Pharmacology 、 Catecholamine 、 Chemistry 、 Dopaminergic 、 Methylphenidate 、 Dopamine 、 Monoamine oxidase
摘要: Modafinil was compared to the indirect dopaminergic drugs, dexamphetamine and methylphenidate, using in vivo differential normal pulse voltammetry with carbon fibre electrodes located caudate nucleus study extracellular catechol level anaesthetized mice. (16–256 mg kg−1) failed modify oxidation peak height (peak 2). Dexamphetamine at low doses (2 4 decreased, while a higher dose (8 did not 2 height. A of methylphenidate (16mg display any effect, (32 64mgkg−1) increased Pargyline-induced monoamine oxidase inhibition elicited rapid dramatic decrease (related levels). In these conditions modafinil (64 256 modify, (2, 8mg (16, 32 relation synaptic dopamine increase. This study, mice, demonstrated lack effects on nigro-striatal function, pre-synaptic level, as opposed methylphenidate.
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