Mechanotransduction and the Myogenic Response in Diabetes

摘要: Tissues of the body possess intrinsic control mechanisms for regulating hemodynamics at local level. These largely occur independently innervation and circulating factors allow blood flow to be matched metabolic requirements. In case myogenic response, or pressure-induced vasoconstriction, this mechanism is dependent on cells vessel wall detecting responding a mechanical stimulus. This event then must conveyed across smooth muscle cell membrane contractile proteins affect an appropriate response. Diabetes related disorders that lead hyperglycemia may interfere with process by either alterations (for example, remodeling events, increased stiffness, decreased distensibility) impairment signal transduction (including ion channel function, Ca2+ handling protein interactions). chapter reviews cellular underlying contraction how these altered in hyperglycemic states.