Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.
作者： Susana Llanos , Paula A. Clark , Janice Rowe , Gordon Peters
DOI: 10.1038/35074506
关键词: Endogeny 、 Suppressor 、 Cell biology 、 p14arf 、 Tumor Suppressor ARF 、 Nucleoplasm 、 Nucleolus 、 Biology 、 Mdm2
摘要: The alternative product of the human INK4a/ARF locus, p14ARF, has potential to act as a tumour suppressor by binding and inhibiting p53 antagonist MDM2. Current models propose that ARF function depends on its ability sequester MDM2 in nucleolus. Here we describe situations which stabilization occur without relocalization endogenous from nucleoplasm. Conversely, forms do not accumulate nucleolus retain capacity stabilize p53. We therefore nucleolar localization is essential for but may enhance availability inhibit
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