Eidetic Analysis of the Premature Chromosome Condensation Process

摘要: An exact transfer of genetic information depends on the accuracy mechanisms duplicating DNA molecules in S-phase and precise division sister chromosomes during mitosis. The regulation systems these processes (checkpoints) not only control activation course factors imposing different metabolic specificity each cell cycle phases, but first all – supervising proper chronology events they condition behavior structural functional genome integrity. Checkpoints receive signals abnormalities or damages to response evoke reactions inhibiting successive transitions through enable expression specific genes repair factors. One easily perceptible effects disorders this signaling system is induction premature chromosome condensation (PCC). present chapter a review ways mode PCC. term ‘PCC’ inseparably associated with Johnson & Rao (1970) their experiments mitosis induced by fusion interphase mitotic HeLa cells (G1/M, S/M G2/M) which were originally carried out using Sendai virus. PCC process can be also chemical signals. Drug-induced provides new knowledge that replication tightly coupled stability results from alternation main objective show possible various subperiods cycle. Moreover, it has been shown there are cause-and-effect relationships between structure defining ‘PCC phenotype’ subperiods, e.g. S-phase, initiating biosynthesis ‘early’ ‘late’ replicons. Attempts have made find answers questions such as: How force break rules being developed Nature for billions years? despite interrupted, still unterminated initiate its division? What annihilate subordination principle verified evolution: create (DNA-duplicating Sphase) then divide (mitosis stage formation