Flurbiprofen for the treatment of primary dysmenorrhea

摘要: Abstract Following the demonstration that Increased prostaglandin F 2α production causes pain similar to dysmenorrhea, and finding synthetase inhibitors are capable of relieving menstrual pain, early theory uterine ischomia has once again gained support as most likely explanation for this condition. In a double-blind, placebo-controlled, crossover study, 30 43 women with moderate severe dysmenorrhea who completed trial preferred flurbiprofen (Ansaid, Upjohn), potent new analgesic/anti-inflammatory agent (50 mg four times daily), aspirin (650 daily) placebo. Flurbiprofen was also rated superior placebo in degree relief. An algorithm diagnosis treatment 90 percent primary is presented.