Multireceptor atypical antipsychotic drugs

摘要: The atypical antipsychotic drugs are those agents which produce fewer extrapyramidal side-effects (EPS) at clinically effective anti-psychotic doses than do the typical neuroleptic [23]. This definition of an drug is still controversial [3]. Various authorities have suggested that term be dropped completely and some other general name used, e.g. novel antipsychotics, while others propose broadened to include features beyond efficacy low EPS, specific pharmacological such as multi-receptor activity, in treatment-resistant schizophrenia, ability improve negative symptoms [3 4]. Clozapine prototypical [5]. It was designated because it differed from were available time its introduction 1960 neuroleptics produced catalepsy rodents EPS man relevant clozapine did not [6]. widely used by preclinical investigators refer their efforts understand biological basis for difference between drug, haloperidol, with regard effects on limbic nigrostriatal dopaminergic systems, probable sites action respectively [7]. Thus, there has been much historical precedent atypicality focuses system differences drugs. Furthermore, acute chronic most significant first generation influence upon compliance, effect, turn relapse rehospitalization [8], well sometimes fatal malignant syndrome, cause tardive dyskinesia [9]. What complicated issue essence discovery many advantages including no known dyskinesia, improvement symptoms, decreased risk suicide, cognition, important [10] (see Naber et al., this volume].