IL-6 treatment increases the survival of retinal ganglion cells in vitro: the role of adenosine A1 receptor.
作者： Rafael Perígolo-Vicente , Karen Ritt , Mariana Rodrigues Pereira , Patrícia Maria Mendonça Torres , Roberto Paes-de-Carvalho
DOI: 10.1016/J.BBRC.2012.12.004
关键词: Cytokine 、 Cell culture 、 Adenosine A1 receptor 、 Retinal ganglion 、 Biology 、 Adenosine receptor 、 Agonist 、 Endocrinology 、 Internal medicine 、 Retina 、 Extracellular
摘要: IL-6 is a pleiotropic cytokine classically denominated pro-inflammatory. It has been already demonstrated that can increase the survival of retinal ganglion cells (RGC) in culture. In this work, we show trophic effect mediated by adenosine receptor (A1R) activation. The neutralization extracellular BDNF abolished and treatment with CHA (an agonist A1R) modulated expression as well pCREB pTrkB levels.
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