FDG-PET/MRI coregistration improves detection of cortical dysplasia in patients with epilepsy

摘要: Objective: Patients with cortical dysplasia (CD) are difficult to treat because the MRI abnormality may be undetectable. This study determined whether fluorodeoxyglucose (FDG)-PET/MRI coregistration enhanced recognition of CD in epilepsy surgery patients. Methods: from 2004–2007 whom FDG-PET/MRI was a component presurgical evaluation were compared patients 2000–2003 without this technique. For cohort, neuroimaging and clinical variables between mild Palmini type I severe II CD. Results: Compared more detected, most had CD, fewer cases required intracranial electrodes. From 2004–2007, 85% normal non–University California, Los Angeles (UCLA) scans. UCLA identified 78% patients, 37% EEG findings concordant 52% 89% FDG-PET scans positive 71% cases, less hypometabolism Postoperative seizure freedom occurred 82% differences cases. Conclusions: Incorporating fluorodeoxyglucose-PET/MRI into multimodality noninvasive identification successful surgical treatment (CD), especially for 33% nonconcordant those GLOSSARY: AED = antiepileptic drug; dysplasia; FDG fluorodeoxyglucose; mMCD malformations development; TLE temporal lobe epilepsy; University Angeles.