Synchronous primary perianal Paget's disease and rectal adenocarcinoma: report of a hitherto undescribed phenomenon.
作者： Chanjuan Shi , Pedram Argani
关键词: Invasive carcinoma 、 Apocrine 、 Rectal Adenocarcinoma 、 Anal canal 、 Perianal Paget's disease 、 Pagetoid 、 Pathology 、 Immunohistochemistry 、 Medicine 、 Paget Disease
摘要: Perianal Paget's disease is rare. It usually represents intraepidermal extension of an invasive carcinoma from adjacent internal organ, but some cases represent primary intraepithelial cutaneous apocrine adenocarcinomas. Here, we report a unique case, which interpret as synchronous perianal and lower rectal adenocarcinoma. Immunohistochemical stains demonstrated that the cells were CK7+/ CK20-/GCDFP+, whereas adenocarcinoma was CK7+(variable)/CK20+/GCDFP-. This discordant immunoprofile supported our impression in this patient origin rather than pagetoid patient's nearby adenocarcinoma-to knowledge hitherto undocumented occurrence.
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