Spermine detection via metal-mediated ethynylarene 'turn-on' fluorescence signaling.
作者： James T. Fletcher , Brent S. Bruck
DOI: 10.1016/J.SNB.2014.10.116
关键词: Spermine 、 Chelation 、 Stereochemistry 、 Bathochromic shift 、 Spermidine 、 Fluorescence 、 Photochemistry 、 Putrescine 、 Polyamine 、 Chemistry 、 Cadaverine
摘要: Abstract A dicarboxylated ethynylarene was shown to behave as a fluorescent chemosensor for millimolar concentrations of polyamines when mixed with Cd(II), Pb(II) or Zn(II) ions at micromolar concentrations. bathochromic shift and intensification fluorescence emission observed increasing amounts metal ion in the presence aqueous buffered pH = 7.6. Such perturbations manifested ‘turn-on’ signals from ratiometric comparison intensities 390 nm versus 340 nm. Using mediator, spermine selectively detected 40-fold signal enhancement relative spermidine, putrescine, cadaverine several other non-biogenic diamines. Evaluation additional triamine tetraamine analytes showed influence that amine group quantity spacing had on generation. By ratio ethynylarene, detection limit successfully lowered 25 level. Noncovalent association between polyamine are believed promote spectroscopic changes. This study exploits subtle impact structural identity has transition chelation define new approach toward development.
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