Effect of CYP2C19*2 and *3 Loss-of-Function Alleles on Platelet Reactivity and Adverse Clinical Events in East Asian Acute Myocardial Infarction Survivors Treated With Clopidogrel and Aspirin

摘要: Background—As compared with whites, East Asians more often carry the cytochrome P450 (CYP) 2C19 loss-of-function (LOF) allele CYP2C19*3 variant. The influence of CYP2C19 LOF alleles (*2 and *3) on clopidogrel response clinical outcomes in acute myocardial infarction (AMI) has not been reported. We sought to evaluate effect variants pharmacodynamics long-term prognosis these patients. Methods Results—Patients who survived an AMI (n=266) were enrolled a single-center registry. Predischarge platelet reactivity was assessed light transmittance aggregometry VerifyNow P2Y12 assay; CYP2C19*2, *3, *17 ABCB1 3435C>T determined. primary end point composite cardiovascular death, nonfatal MI, ischemic stroke. median exposure 21 months (interquartile range, 13–29). related or events. Carri...