Oxidative and nitrosative stress and fibrogenic response.

摘要: Uncontrolled production of collagen I is the main feature liver fibrosis. Following a fibrogenic stimulus such as alcohol, hepatic stellate cells (HSC) transform into an activated collagen-producing cell. In alcoholic disease, numerous changes in gene expression are associated with HSC activation, including induction several intracellular signaling cascades, which help maintain phenotype and control proliferative state Detailed analyses for understanding molecular basis regulation have revealed complex process involving reactive oxygen species (ROS) key mediators. Less known, however, about contribution nitrogen (RNS). addition, series cytokines, growth factors, chemokines, activate extracellular matrix (ECM)-producing through paracrine autocrine loops, contribute to response.