10 The Stem Cell-Targeting Drug Salinomycin Inhibits Proliferation of Normal, Benign Hyperplastic, and Transformed Interstitial Cells of Cajal and Their Stem Cells (ICC-SC) by Increasing the Expression of Cell Cycle Restriction Checkpoint Regulators

摘要: the index colonoscopy to first of following: 10 years follow-up; performance another without CRC; termination membership; diagnosis or January 31, 2011. CRCs occurring within 6 months after were excluded. Analyses used multi-level Cox proportional hazards models with clustering on physician. Potential predictors subsequent CRC risk included physician ADR, exam type, and patient sex, age, race/ethnicity, family history CRC, Charlson comorbidity score. Hazard ratios (HR) for calculated separately by sex both sexes combined, distal proximal location (both combined). Results: We identified 316,334 exams 716 post-colonoscopy cases analyses. Patients combined) whose colonoscopies performed endoscopists lower ADRs more likely be diagnosed than patients had a higher ADR. The adjusted HRs (and CIs) ADR quartiles ,20.3%, 20.3%-25.2%, 25.3%-32.0%, as compared ≥32.1%, 1.74 (1.36, 2.24), 1.52 (1.14, 2.04), 1.31 (1.00, 1.73), respectively (Table). relationships between similar Finally, linear relationship did not vary sex. Conclusions: Physician is an independent predictor following negative colonoscopy, does cancers. use quality measure colonoscopy’s ability prevent cancers appears warranted; cancer increases linearly decreasing there was no clear threshold above which further improvement.