Signs, symptoms and the prevalence of fungi detected from the oral cavity and pharynx of radiotherapy subjects with head and neck tumors, and their susceptibility to chemotherapeutics.

摘要: Radio- and chemotherapy for malignant neoplasms, especially in head neck region, is associated with a greater risk of fungal infections due to secondary alterations the mucous membranes. The study had three aims: 1.to determine signs symptoms which occur among patients undergoing radiotherapy; 2. fungi prevalence mouth throat before, during after 3. examine sensitivity strains antimycotic drugs. comprised 44 (11 female, 33 male) cancers,examined at following stages: before radiotherapy (44 – batch 1), 3rd week therapy (30 patients– 2), last day (28 2 3) 6th completion (10 3 4). Clinical examination was performed mycological status estimated from an oral rinse on selected medium. were isolated antifungal drugs determined. most common pain, dysphagia, dysgeusia. Physical revealed mucositis mainly batches presence noted over 2/3 (66.2%) 1, 4/5 (80%) detected half (57.1%) also 4. In all cases, various Candida species identified: 6 1,8 2, 5 frequently C. albicans, constituting 40–60%;the other are known be resistant sensitive nystatin miconazole, least ketoconazole fluconazole. Conclusions: 1. Patients complain dysgeusia; cases diagnosed. high treated by reinforces need perform examinations this group detect fungi, identify their order prevent complications. albicans C.glabrata. latter characterized resistance majority medications. Most miconazole (applied locally) itraconazole (absorbed gastrointestinal tract).