Gadolinium nicotinate clusters as potential MRI contrast agents
作者： Xinping Lin , Qiongqiong Zhang , Jiahe Chen , Xiangjian Kong , La-Sheng Long
DOI: 10.1039/C4RA07853E
关键词: Gadolinium 、 Nuclear magnetic resonance 、 Molecule 、 Chemistry 、 Magnetic resonance imaging 、 Ligand 、 Cluster (physics)
摘要: Three multinuclear gadolinium(III) clusters containing the nicotinate (nic) ligand, [Gd2(nic)6(H2O)4] (1), [Gd4(μ3-OH)4(Hnic)5(H2O)12](ClO4)8·7H2O (2), and [Gd4(μ3-OH)4(nic)6(H2O)6]2(ClO4)4·4H2O (3) were synthesized characterized. Potential applications of these Gd(III) as high-field magnetic resonance imaging (MRI) contrast agents evaluated. The longitudinal relaxivities (r1) 1–3 in water at 7 T determined to be 10.45 ± 0.16, 9.28 0.06, 2.04 0.29 mM−1 s−1 on a per Gd ion basis, respectively. In 1% agarose solution, r1 values increased slightly 10.37 0.31, 10.74 0.11, 4.60 for 1–3, ability tune number inner-sphere molecules, cluster sizes, organic ligands, coordination modes such provide interesting opportunities further enhance MR potential MRI applications.
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