Toxicity of Hydrocarbons and Their Halogenated Derivatives in an Aqueous Environment

摘要: The interactions between hydrocarbons and halogenated biological tissues have frequently been shown to be physical rather than chemical in nature, i.e., the substances cause their effect purely by molecular presence some biophase. Even where a breakdown or oxidation product of these is known active main toxicant, properties original compound may determine transport from external environment site toxic action within tissue. Ferguson (1939) showed that equitoxic concentrations physically acting chemicals had similar thermodynamic activity, which at equilibrium would uniform throughout various biophases. In simple terms this means toxicity occurs degrees aqueous saturation — lower water solubility effective concentration. concept equitoxicity constant activity has confirmed since investigators working widely diverse areas toxicology.