Nanotoxicology: Contemporary Issues and Future Directions
作者： Chandraiah Godugu , Raman Preet Singh , Ramarao Poduri
DOI: 10.1007/978-3-319-11355-5_23
关键词: Toxicity 、 Proinflammatory cytokine 、 Cell biology 、 Cytotoxicity 、 Gene delivery 、 MAPK/ERK pathway 、 Transcription factor 、 Programmed cell death 、 Chemistry 、 Nanotoxicology
摘要: Different types of nanomaterials possess excellent physical and chemical properties. Nanoparticles (NPs) have been implicated for use in drug gene delivery. Several vitro vivo studies suggest the cytotoxic proinflammatory potential NPs. Further, parenteral administration NPs results their accumulation several tissues. The possible mechanism toxicity appears to be production free radicals, mitogen activated protein kinase (MAPK) activation translocation transcription factors from cytoplasm nucleus. This leads induction apoptosis, growth arrest, cell death. like nuclear factor-κB (NF-κB) lead cytokines. present review focuses on cytotoxicity, biodistribution, with special emphasis carbon nanotubes (CNTs) toxicity.
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