RNA Processing and mRNA Surveillance in Monogenic Diabetes

摘要: In the eukaryotic cell a number of molecular mechanisms exist to regulate nature and quantity transcripts intended for translation. For monogenic diabetes an understanding these processes is aiding scientists clinicians in studying managing this disease. Knowledge RNA processing mRNA surveillance pathways helping explain disease mechanisms, form genotype-phenotype relationships, identifying new regions within genes screen mutations. Furthermore, recent insights into regulatory role micro RNAs (miRNAs) editing pancreas suggests that may also be important progression diabetic state.