The distribution of important sero-complexes of flaviviruses in Malaysia

摘要: Flaviviruses (FVs) are arthropod-borne viruses of medical and veterinary importance. Numerous species FVs have been isolated from various host; mainly humans, animals, ticks, mosquitoes. Certain extremely host-specific; at the same time, some can infect an extensive range species. Based on published literatures, 11 detected diverse host in Malaysia. In dengue virus Japanese encephalitis reported since 1901 1942. Batu Cave virus, Sitiawan Carey Island, Tembusu Duck were mosquitoes, Kunjin Culex spp., while Zika Jugra Aedes spp. Langat was Ixodes One major challenges diagnosis is presence sero-complexes as a result cross-reactivity with one or more FV Subsequently, distribution specific among humans animals population problematic to assess often require comprehensive thorough analyses. Molecular assays such quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) digital droplet RT-PCR (ddRT-PCR) used for differentiation flavivirus infections increase accuracy epidemiological data disease surveillance, monitoring, control. situations where common FVs, even sensitive qRT-pCR produce false positive results. this write up, overview Malaysia date faced presented.