Identification of biomechanical properties in vivo in human uterine cervix

摘要: Abstract Background and aims The course outcome of pregnancy is closely correlated to change biomechanical properties the uterine cervix. aim this study was build a non-linear, fiber reinforced mechanical model cervix for estimation characteristics in early- term-pregnant women based on recordings vivo pressure diameter by means Functional Luminal Imaging Probe (FLIP) technology. Materials methods Five six were examined with FLIP probe. bag probe inserted into cervical canal concomitant measurement diameters at 16 serial locations along pressure. inflated maximum volume 50 ml. A three-fiber-families including isotropic elastin-dominated matrix anisotropic collagen introduced describe behavior canal. unknown geometric parameters calculated basis mid-cervical intraluminal pressures during inflation. Results wall thickness unloaded state (zero applied) material ( c ) collagens 1 , 2 estimated good fits distension. No significant difference found between (10.3±0.8 mm vs . 11.7±2.2 mm, p =0.30). early-pregnant much stiffer than that Conclusions can be obtained from recorded data via established model. Matrix remodeled pregnancy. applied other tubular visceral organs where measures better understanding diseases their evolution or treatment.