‘Closing the loop’ in biological systems modeling — From the in silico to the in vitro
作者： Alexandros Kiparissides , Michalis Koutinas , Cleo Kontoravdi , Athanasios Mantalaris , Efstratios N. Pistikopoulos
DOI: 10.1016/J.AUTOMATICA.2011.01.013
关键词: Experimental validation 、 Biological modeling 、 In silico 、 Computer science 、 Mathematical model 、 LOOP (programming language) 、 Systems engineering 、 Systems modeling 、 Closing (morphology) 、 Work (electrical)
摘要: This work presents a holistic 'closed loop' approach for the development of models biological systems. The ever-increasing availability experimental information necessitates advancement systematic methodology to organise and utilise these data. Herein, we present model building framework that maps treatment from initial conception model, through its validation finally application in model-based optimisation studies. We highlight discuss current issues associated with mathematical systems share our perspective towards will facilitate control vitro silico.
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