Combination chemotherapy with paclitaxel and intraperitoneal cisplatin for ovarian cancer with disseminated lesions in the peritoneum and the diaphragm.

摘要: Background: In ovarian cancer, the management of micrometastases disseminated in peritoneal cavity is extremely important. We performed intravenous paclitaxel (PAC) infusion combined with cisplatin (CDDP) intraperitoneal for progressive cancer. Methods: Twelve patients epithelial cancer (FIGO IIIc), which was resected using an optimal method at primary surgery, except lesions peritoneum and diaphragm, were studied. At a reservoir placed cavity. If metastases identified then another also subdiaphragm (double reservoirs). The basic regimen set 175 mg/m2 divided doses PAC 75 mg/m2 CDDP by injection. When double used, 30 mg/m2 subdiaphragmatic 45 mg/m2 administered. received five courses this regimen. response to therapy evaluated tumor markers, cytodiagnoses on washing fluid collected from reservoirs. Results: After chemotherapy, marker levels all became negative. With reference adverse effects, grade 3–4 neutropenia detected 2 (16.6%), peripheral neuropathy 4 (33.3%), alopecia 11 (91.6%). median follow-up period 29.2 months progression-free survival 25.6 months. Conclusion: combination chemotherapy effective having only mild effects.