Comparative analyses of metabolic fingerprint integrated with cytotoxic activity and in silico approaches of the leaves extract of Spondias mombin L. and Spondias tuberosa Arr. Cam. from Northeast, Brazil

摘要: Abstract Spondias species are a relevant source of natural-bioactive compounds in Brazilian folk medicine, and its biological potential has not been explored. Thus, this study aimed to determine the metabolomic fingerprint mombin tuberosa leaves based on use reversed-phase liquid chromatography coupled high-resolution mass spectrometer (UPLC-HRMS). The analysis by UPLC-HRMS allowed annotation 31 metabolites. multivariate us identify biomarkers responsible for distinction between species. Also, we correlate S. as supposed difference degree cytotoxicity them. silico evaluation was performed give more consistency correlation cytotoxicity, which were compared commercial drugs. Therefore, showed that become an input pharmaceutical industry raw material can positively impact sectors agricultural production.