Self-Assembling Nanoparticles of Amphiphilic Polymers for In Vitro and In Vivo FRET Imaging

摘要: Self-assembling nanoparticles of amphiphilic polymers are viable delivery vehicles for transporting hydrophobic molecules across hydrophilic media. Noncovalent contacts between the domains their macromolecular components responsible formation and providing a nonpolar environment encapsulated guests. However, such interactions reversible and, as result, these supramolecular hosts can dissociate into constituents amphiphiles to release cargo. Operating principles probe integrity nanocarriers dynamic exchange are, therefore, essential monitor fate assemblies in biological The co-encapsulation complementary chromophores within interior offers opportunity assess stability on basis energy transfer fluorescence measurements. Indeed, excitation entrapped only occur if retain maintain donors acceptors close proximity. In fact, energy-transfer schemes becoming invaluable protocols elucidate transport properties fascinating constructs diversity preparations facilitate identification strategies deliver contrast agents and/or drugs target locations living organisms potential diagnostic therapeutic applications.