Acetaminophen-induced Acute Liver Failure Is More Common and More Severe in Women

摘要: Background & Aims Acetaminophen overdose is the leading cause of acute liver injury (ALI) and failure (ALF) in developed world. Sex differences acetaminophen-induced hepatotoxicity have not been described. Methods We collected data from Acute Liver Failure Study Group cohort, a national registry 32 academic medical centers North America adults with ALI or ALF, including 1162 patients (n = 250) ALF 912) January 2000 through September 2016. analyzed on patient presentation, disease course, demographics, psychiatric history, medication use, substance details acetaminophen ingestion. continuous categorical variables were evaluated by Wilcoxon rank-sum χ 2 analysis Fisher exact test. Our primary aim was to evaluate sex presentation clinical course failure, our secondary goal compare overall transplant-free survival between sexes. Results Most (68%) (76%) women. Higher proportions women than men had (60% vs 48% of men, P values  = .04) mannitol (13% 6% men, .12). Conclusions In an we found be more common among Women greater critical care needs increased risk for severe HE, which could due part use sedatives. Future studies should investigate metabolism hepatotoxicity, particularly users opioids.