Application of centrifugal counter-current chromatography to the separation of macrolide antibiotic analogues: I. Selection of solvent systems based on solubility and partition coefficient investigations
作者： Weizheng Wang-Fan , Ernst Küsters , Olivier Lohse , Ching-Pong Mak , Ying Wang
DOI: 10.1016/S0021-9673(99)01012-2
关键词: Partition coefficient 、 Solubility 、 Countercurrent chromatography 、 Selectivity 、 Methanol 、 Chemistry 、 Ascomycin 、 Solvent 、 Ternary operation 、 Chromatography
摘要: As the first part of our studies on counter-current chromatography, methodology for selecting suitable solvent systems was established based detailed investigations solubility and partition coefficients (log K) macrolide antibiotic analogues. The two important macrolides, ascomycin FK-506, measured in a series common solvents, where their polarities were ranked with dielectric constants. macrolides compared various binary, ternary, quaternary systems. Hexane-tert.-butyl methyl ether-methanol-water system selected log K solutes hydrogen-bonding properties solvents. In further optimisation composition proportions multicomponent system, hexane-tert.-butyl (1:3:6:5) showed best selectivity by giving most prominent difference coefficient (delta between FK-506. With this baseline preparative separation these very closely related 23-membered antibiotics successfully achieved employing newly introduced Quattro chromatograph.
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