Pretargeted activatable cell penetrating peptide with intracellularly releasable prodrug

摘要: Disclosed herein, the invention pertains to methods and compositions that find use in treatment, diagnosis, prognosis characterization of disease samples based on ability a sample cleave MTS molecule present invention. The molecules have formula as disclosed herein wherein A is peptide with sequence comprising 5 9 consecutive acidic amino acids, acids are selected from: aspartates glutamates; B 20 basic acids; X Y linkers; P pre-targeting moiety; M macromolecular carrier, C detectable T compound for delivery target, including example therapeutic compound.