Regioselective copper-catalyzed thiolation of imidazo[1,2-a]pyridines: an efficient C–H functionalization strategy for C–S bond formation
作者： Hua Cao , Longbin Chen , Jingyun Liu , Huiyin Cai , Hao Deng
DOI: 10.1039/C5RA01342A
关键词: Bond formation 、 Molecular oxygen 、 Organic chemistry 、 Surface modification 、 Medicinal chemistry 、 Catalysis 、 Chemistry 、 Regioselectivity 、 Copper 、 Copper catalyzed
摘要: A highly regioselective C–H/S–H cross-coupling of imidazo[1,2-a]pyridines with thiols has been developed using molecular oxygen to form the C-3 sulfenated products in presence a copper catalyst. It represents simple process for formation C–S bonds prepare thioether-decorated imidazo[1,2-a]pyridines. The reaction proceeds smoothly broad range substrates give good yields.
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