Risk Factors of Ketosis in Obese Ketosis-Prone Diabetic Patients: A Case-Control Study

摘要: Different types of ketosis-prone obese diabetic patients are seen in the clinic. At present, mechanism responsible for ketosis onset these remains unclear, and we do not know how should be optimally treated to prevent recurrent ketosis. Therefore, this study aims investigate risk factors (OB-KPD) patients. In an observational case-control study, primary OB-KPD [body mass index (BMI) ≥ 28 kg/m2] were selected as group (OB-KPD group), type 2 diabetes served control (OB-T2DM group). Clinical diagnostic assessments fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), blood lipid, area under curve serum C-peptide (AUCC-P) after steamed bread meal, insulin sensitivity (ISI), β-hydroxybutyric acid (β-HB) free fatty (FFA) vlaues subjects collected. Subjects followed up 1 year determine likelihood therapy cessation whether recurred by assessing clinical chemistry parameters at 1-year follow-up. Seventy-five screened, which 15 included several identified reasons. On enrollment, displayed significantly higher FPG, HbA1c FFA levels than OB-T2DM (p < 0.01), while AUCC-P ISI values lower (p < 0.01 p = 0.03). Statistical analysis showed that increases β-HB associated with increased decreased values. Furthermore, decreases closely The occurrence may related lipid metabolism disorders, resistance β-cell secretory functions. This work was registered Chinese Trial Registry trial registration identifier no. ChiCTR1900025909.