Calcium-activated potassium currents in mammalian neurons.

摘要: 1. Influx of calcium via voltage-dependent channels during the action potential lends to increases in cytosolic that can initiate a number physiological processes. One these is activation potassium currents on plasmalemma. These calcium-activated contribute repolarization and are largely responsible for phenomenon spike frequency adaptation. This refers progressive slowing discharge potentials sustained injection depolarizing current. In some cell types, this adaptation so marked despite presence current, only single (or few spikes) initiated, Following cessation current injection, slow deactivation also prolonged hyperpolarization often follows, 2. A macroscopic be separated basis kinetic pharmacological criteria have been described mammalian neurons. At channel level, several types characterized. While underlying:single unambiguously defined, other identity underlying not clear. 3. present review we describe properties known neurons indicate relationship between particular channels.