Protective and antigenotoxic effect of Ulva rigida C. Agardh in experimental hypothyroid.
作者： Serap Celikler , Sibel Tas , Sedef Ziyanok-Ayvalik , O. Vatan , Gamze Yildiz
DOI: 10.1556/ABIOL.65.2014.1.2
关键词: Micronucleus test 、 Genotoxicity 、 Chemistry 、 Internal medicine 、 Phytotherapy 、 Oxidative stress 、 Oral administration 、 Micronucleus 、 Endocrinology 、 Hormone 、 Thyroid
摘要: The presence of chromosomal damage in bone marrow cells affected by several diseases such as thyroid, cancer etc., was detected the micronucleus (MN) assay. present study designed to evaluate: i) volatile components Ulva rigida, ii) effects hypothyroidism on MN frequency, iii) oral administration rigida ethanolic extract (URE) frequency produced hypothyroidism, and iv) thyroid hormone levels normal 6-n-Propylthiouracil (PTU)-induced hypothyroid rats. studied using a direct thermal desorption (DTD) technique with comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GCxGC-TOF/MS). URE no significant impact control group, while PTU decreased compared group (p < 0.001). Moreover, supplementation resulted decrease each 0.0001). This is first vivo that shows strong antigenotoxic protective effect against genotoxicity hypothyroidism.
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