Human immunodeficiency virus can productively infect cultured human glial cells.

摘要: Abstract Six isolates of the human immunodeficiency virus (HIV) showed differences in their ability to productively infect glioma-derived cell lines and early-passage brain cultures. Susceptibility HIV infection correlated well with expression astrocyte marker glial fibrillary acidic protein. The CD4 molecule was expressed on some, but not all, brain-derived cells; however, no correlation observed between protein susceptibility infection. results show that can cells, particularly those origin, suggest these types harbor virus.