Glucose-Dependent Insulinotropic Polypeptide Is a Growth Factor for β (INS-1) Cells by Pleiotropic Signaling
作者： Andrea Trümper , Katja Trümper , Heidi Trusheim , Rudolf Arnold , Burkhard Göke
关键词: Insulin receptor substrate 、 MAPK/ERK pathway 、 Insulin receptor 、 Protein kinase B 、 Signal transduction 、 Growth factor 、 Janus kinase 2 、 Biology 、 Receptor 、 Biochemistry
摘要: Activation of the G-protein-coupled receptor for glucose-dependent insulinotropic polypeptide facilitates insulin-release from pancreaticβ -cells. In present study, we examined whether also acts as a growth factor theβ -cell line INS-1. Here, show that induced cellular proliferation synergistically with glucose between 2.5 mm and 15 by pleiotropic activation signaling pathways. Glucose-dependent stimulated modules PKA/cAMP regulatory element binder, MAPK, PI3K/protein kinase B in glucose- dose-dependent manner. Janus 2 signal transducer activators transcription 5/6 pathways were not polypeptide. PI3K was associated insulin substrate isoforms substrate-2 bound-2 a...
oup.com
endocrine.org
sci-hub.se 参考文章(50)
Sushil G Rane, E Premkumar Reddy, Cell cycle control of pancreatic beta cell proliferation. Frontiers in Bioscience. ,vol. 5, ,(2000) , 10.2741/RANE
Jens Høiriis Nielsen, Annette Møldrup, Nils Billestrup, Elisabeth Douglas Petersen, Giovanna Allevato, Matthias Stahl, The role of growth hormone and prolactin in beta cell growth and regeneration. Advances in Experimental Medicine and Biology. ,vol. 321, pp. 9- 20 ,(1992) , 10.1007/978-1-4615-3448-8_2
R Scharfmann, P Czernichow, Differentiation and growth of pancreatic beta cells. Diabetes & Metabolism. ,vol. 22, pp. 223- 228 ,(1996)
Mario Pende, Sara C. Kozma, Muriel Jaquet, Viola Oorschot, Rémy Burcelin, Yannick Le Marchand-Brustel, Judith Klumperman, Bernard Thorens, George Thomas, Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice. Nature. ,vol. 408, pp. 994- 997 ,(2000) , 10.1038/35050135
Stefan Susini, Enrique Roche, Marc Prentki, Werner Schlegel, Glucose and glucoincretin peptides synergize to induce c-fos, c-jun, junB, zif-268, and nur-77 gene expression in pancreatic β(INS-1) cells The FASEB Journal. ,vol. 12, pp. 1173- 1182 ,(1998) , 10.1096/FASEBJ.12.12.1173
Paul J. COFFER, Jing JIN, James R. WOODGETT, Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochemical Journal. ,vol. 335, pp. 1- 13 ,(1998) , 10.1042/BJ3350001
Simeon I Taylor, Deconstructing type 2 diabetes. Cell. ,vol. 97, pp. 9- 12 ,(1999) , 10.1016/S0092-8674(00)80709-6
Susanne G. Straub, Geoffrey W.G. Sharp, Glucose-Dependent Insulinotropic Polypeptide Stimulates Insulin Secretion via Increased Cyclic AMP and [Ca2+]iand a Wortmannin-Sensitive Signalling Pathway Biochemical and Biophysical Research Communications. ,vol. 224, pp. 369- 374 ,(1996) , 10.1006/BBRC.1996.1035
R. A. DeFronzo, E. Ferrannini, Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease Diabetes Care. ,vol. 14, pp. 173- 194 ,(1991) , 10.2337/DIACARE.14.3.173
Akira Kubota, Yuichiro Yamada, Koichiro Yasuda, Yoshimichi Someya, Yu Ihara, Shinji Kagimoto, Rie Watanabe, Akira Kuroe, Hitoshi Ishida, Yutaka Seino, Gastric inhibitory polypeptide activates MAP kinase through the wortmannin-sensitive and -insensitive pathways. Biochemical and Biophysical Research Communications. ,vol. 235, pp. 171- 175 ,(1997) , 10.1006/BBRC.1997.6743