Self-reported onset of puberty and subsequent semen quality and reproductive hormones in healthy young men.

摘要: STUDY QUESTION Is there an association between pubertal onset and subsequent reproductive health in young men? SUMMARY ANSWER Self-reported later of puberty was associated with reduced semen quality altered serum levels hormones among 1068 healthy, Danish men. WHAT IS KNOWN ALREADY The long-term effects variations the male on reproduction remain largely unstudied. DESIGN, SIZE, DURATION In a cross-sectional study, healthy men were approached when they attended compulsory medical examination to determine their fitness for military service from 2008 2012. PARTICIPANTS/MATERIALS, SETTINGS, METHODS A total (mean age 19 years) participated. They asked assess whether penile testicular growth, development pubic hair voice break occurred earlier, at same time as or than peers. Their (semen volume, sperm concentration, count percentages motile morphologically normal spermatozoa) concentrations sex (LH, FSH, testosterone, SHBG, inhibin B) size determined. MAIN RESULTS AND THE ROLE OF CHANCE response rate 29%. Of who then participated, 652 answered questions about growth therefore included analysis. 25% reduction concentration (95% CI -41%; -4%), 40% (-55%; -21%), 1.6% point morphological spermatozoa (-2.9; -0.3) 1.6 ml (-2.4 -0.8 ml), after adjustment confounders. also 9% (3%; 15%) free testosterone 16% (2%; 31%) increase LIMITATIONS, REASON FOR CAUTION Our study reverse causality cannot be ruled out. addition, we rule out possibility that late had not yet fully matured although most Tanner stage 5. WIDER IMPLICATIONS FINDINGS Approximately 15% have self-reported We found poorer function history development, suggesting timing may fundamental marker health. However, exclude these improve, which makes follow-up important. FUNDING/COMPETING INTERESTS This work supported by Council Strategic Research, Program Commission Health, Food Welfare (project number 2101-08-0058), Rigshospitalet (grants 961506336 R42-A1326), European Union, DEER (grant agreement no 212844), Ministry Health Environmental Protection Agency Kirsten Freddy Johansens Foundation 95-103-72087). There are competing interests.