Executive function in schizophrenia.
作者： C. C. Bow-Thomas , Dawn I Velligan
DOI: 10.1053/SCNP00400024
关键词: Function (engineering) 、 Cognition 、 Atypical antipsychotic 、 Functional brain 、 Cognitive rehabilitation therapy 、 Schizophrenia 、 Clinical psychology 、 Affect (psychology) 、 In patient 、 Psychology
摘要: Many domains of executive function are impaired in patients with schizophrenia including forward planning, concept formation, initiation, self-monitoring, and the ability to direct attention memory. These impairments noticeable against a background generalized cognitive deficits, many affect 40% 95% individuals this disorder. Specific deficits appear be related specific symptom clusters linked structural functional brain abnormalities. Executive impairment predicts multiple outcome patients. Atypical antipsychotic agents rehabilitation may promising new approaches for treatment schizophrenia.
utsystem.edu参考文章(42)
Patrick Rabbitt, Introduction: Methodologies and models in the study of executive function Psychology Press. pp. 9- 45 ,(2004) , 10.4324/9780203344187-5
Joaquin M. Fuster, The Prefrontal Cortex: Anatomy, Physiology, and Neuropsychology of the Frontal Lobe ,(1980)
Rajiv Tandon, James E. Shipley, John F. Greden, Nancy A. Mann, William H. Eisner, JoAnn Goodson, Muscarinic cholinergic hyperactivity in schizophrenia. Relationship to positive and negative symptoms. Schizophrenia Research. ,vol. 4, pp. 23- 30 ,(1991) , 10.1016/0920-9964(91)90006-D
What are the functional consequences of neurocognitive deficits in schizophrenia American Journal of Psychiatry. ,vol. 153, pp. 321- 330 ,(1996) , 10.1176/AJP.153.3.321
Paul W. Burgess, Theory and Methodology in Executive Function Research In: Rabbitt, P., (ed.) Theory and Methodology of Frontal and Executive Function. (pp.81 - 116 ). Psychology Press: East Sussex, UK. (1997). pp. 87- 121 ,(1997) , 10.4324/9780203344187-8
P A Thompson, M A Lee, H Y Meltzer, Effects of clozapine on cognitive function in schizophrenia. The Journal of Clinical Psychiatry. ,vol. 55, pp. 82- 87 ,(1994)
Barbara A. Cornblatt, Mark F. Lenzenweger, L. Erlenmeyer-Kimling, The continuous performance test, identical pairs version: II. Contrasting attentional profiles in schizophrenic and depressed patients Psychiatry Research. ,vol. 29, pp. 65- 85 ,(1989) , 10.1016/0165-1781(89)90188-1
Dawn I. Velligan, Roderick K. Mahurin, Pamela L. Diamond, Bonnie C. Hazleton, Stacey L. Eckert, Alexander L. Miller, The functional significance of symptomatology and cognitive function in schizophrenia Schizophrenia Research. ,vol. 25, pp. 21- 31 ,(1997) , 10.1016/S0920-9964(97)00010-8
Barbara A. Cornblatt, Neil J. Risch, Gerald Faris, David Friedman, L. Erlenmeyer-Kimling, The Continuous Performance Test, identical pairs version (CPT-IP): I. New findings about sustained attention in normal families. Psychiatry Research-neuroimaging. ,vol. 26, pp. 223- 238 ,(1988) , 10.1016/0165-1781(88)90076-5
Sohee Park, Philip Holzman, P Goldman-Rakic, Spatial Working Memory Deficits in the Relatives of Schizophrenic Patients Archives of General Psychiatry. ,vol. 52, pp. 821- 828 ,(1995) , 10.1001/ARCHPSYC.1995.03950220031007