The N-end rule: functions, mysteries, uses
作者： A. Varshavsky
关键词: Protein structure 、 Identity (mathematics) 、 Fungal protein 、 Ubiquitin 、 Ubiquitin-Protein Ligases 、 Computational biology 、 N-end rule 、 Proto-Oncogene Proteins c-mos 、 Biology 、 A protein 、 Genetics
摘要: Abstract The N-end rule relates the in vivo half-life of a protein to identity its N-terminal residue. Similar but distinct versions operate all organisms examined, from mammals fungi and bacteria. In eukaryotes, pathway is part ubiquitin system. I discuss mechanisms functions this pathway, consider applications.
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