Epigenetics of the Synapse in Neurodegeneration
作者： Mary Xylaki , Benedict Atzler , Tiago Fleming Outeiro
DOI: 10.1007/S11910-019-0995-Y
关键词: Epigenetics 、 Neuronal degeneration 、 Neuroscience 、 Transcriptome 、 Biology 、 Degeneration (medical) 、 Neurodegeneration 、 Postmortem brain 、 DNA methylation 、 Synapse
摘要: In the quest for understanding pathophysiological processes underlying degeneration of nervous systems, synapses are emerging as sites great interest synaptic dysfunction is thought to play a role in initiation and progression neuronal loss. particular, synapse an interesting target effects epigenetic mechanisms neurodegeneration. Here, we review recent advances on driving compromise major neurodegenerative disorders. Major developments sequencing technologies enabled mapping transcriptomic patterns human postmortem brain tissues various diseases, also cell animal models. These studies helped identify changes classical neurodegeneration pathways discover novel targets related degeneration. Identifying indicative defects prior may provide basis future breakthroughs field
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sci-hub.se 参考文章(110)
Hilary A. A. Colyer, Richard N. Armstrong, Ken I. Mills, Microarray for epigenetic changes: gene expression arrays. Methods of Molecular Biology. ,vol. 863, pp. 319- 328 ,(2012) , 10.1007/978-1-61779-612-8_20
Roberto Fiore, Sharof Khudayberdiev, Reuben Saba, Gerhard Schratt, MicroRNA function in the nervous system. Progress in Molecular Biology and Translational Science. ,vol. 102, pp. 47- 100 ,(2011) , 10.1016/B978-0-12-415795-8.00004-0
Timothy Bestor, Andrew Laudano, Robert Mattaliano, Vernon Ingram, Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells: The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases☆ Journal of Molecular Biology. ,vol. 203, pp. 971- 983 ,(1988) , 10.1016/0022-2836(88)90122-2
Gary E. Marchant, Mark A. Rothstein, Yu Cai, The Ghost in Our Genes: Legal and Ethical Implications of Epigenetics Social Science Research Network. ,(2009)
Stefanie Jonas, Elisa Izaurralde, Towards a molecular understanding of microRNA-mediated gene silencing Nature Reviews Genetics. ,vol. 16, pp. 421- 433 ,(2015) , 10.1038/NRG3965
Karina Hernández-Ortega, Paula Garcia-Esparcia, Laura Gil, José J. Lucas, Isidre Ferrer, Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome Brain Pathology. ,vol. 26, pp. 593- 605 ,(2016) , 10.1111/BPA.12335
D.M. Woodcock, P.J. Crowther, W.P. Diver, The majority of methylated deoxycytidines in human DNA are not in the CpG dinucleotide Biochemical and Biophysical Research Communications. ,vol. 145, pp. 888- 894 ,(1987) , 10.1016/0006-291X(87)91048-5
Xintian You, Irena Vlatkovic, Ana Babic, Tristan Will, Irina Epstein, Georgi Tushev, Güney Akbalik, Mantian Wang, Caspar Glock, Claudia Quedenau, Xi Wang, Jingyi Hou, Hongyu Liu, Wei Sun, Sivakumar Sambandan, Tao Chen, Erin M Schuman, Wei Chen, Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity Nature Neuroscience. ,vol. 18, pp. 603- 610 ,(2015) , 10.1038/NN.3975
Alexander Figurov, Lucas D. Pozzo-Miller, Petur Olafsson, Ti Wang, Bai Lu, Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus Nature. ,vol. 381, pp. 706- 709 ,(1996) , 10.1038/381706A0
Tara L. Spires-Jones, Bradley T. Hyman, The intersection of amyloid beta and tau at synapses in Alzheimer’s disease Neuron. ,vol. 82, pp. 756- 771 ,(2014) , 10.1016/J.NEURON.2014.05.004