Divergent Differentiative Histogenetic Lines in Lung Tumors: Identification of Histotypes with Pure or Mixed Ultrastructural Phenotype and Their Prognostic Significance

摘要: We performed an electron microscopic study of 50 lung tumors, previously diagnosed by light microscopy, and compared the results two techniques. Data analysis identified ultrastructural phenotypes: pure mixed. The former was characterized a constant differentiative pattern latter diverging histogenetic lines. observed six lines as follows: squamous, glandular, neuroendocrine, villopodial, intestinal, apocrine sudoriparous. Features divergent were in 36 cases (64%), throughout histotypes, sometimes with coexpression more than one differentiation single case and/or cell. Adenocarcinoma histotype most frequently form whereas squamous cell carcinomas showed mixed phenotype. This suggests that different tumors arises from glandular pluripotent cell, able to differentiate toward clinical stage at onset end follow-up indicates biologic behavior varies according whether phenotype is or