Arachidonic acid-induced human platelet aggregation and prostaglandin formation.
作者： M.J. Silver , J.B. Smith , C. Ingerman , J.J. Kocsis
DOI: 10.1016/0090-6980(73)90121-4
关键词: Albumin 、 Pharmacology 、 Chemistry 、 Hemostasis 、 Platelet 、 Epinephrine 、 Biochemistry 、 Adenosine 、 Arachidonic acid 、 Aspirin 、 Therapeutic index
摘要: Abstract Arachidonic acid and several of its salts caused aggregation platelets in platelet-rich plasma. Other fatty acids did not cause when tested under similar conditions. Platelet induced by arachidonic was inhibited adenosine, β naphthol, non-steroidal anti-inflammatory agents, unsaturated albumin. At concentrations too low to aggregation, enhanced collagen, ADP or epinephrine. form PGE 2 PGF 2α . However, it failed induce prostaglandin synthesis platelet plateletrich plasma obtained one hour after the ingestion a therapeutic dose aspirin. This effect aspirin persisted for days. The significance these findings relation hemostasis thrombosis is discussed.
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