Human heart failure: is cell therapy a valid option?
作者： Marcello Rota , Annarosa Leri , Piero Anversa
DOI: 10.1016/J.BCP.2013.10.031
关键词: Myocyte 、 Progenitor cell 、 Biology 、 Neuroscience 、 Bone marrow 、 Stem cell 、 Immunology 、 Mesenchymal stem cell 、 Cell therapy 、 Myocardial infarction 、 Heart failure
摘要: The concept of the heart as a terminally differentiated organ incapable replacing damaged myocytes has been at center cardiovascular research and therapeutic development for past 50 years. progressive decline in myocyte number with aging formation scarred tissue following myocardial infarction have interpreted irrefutable proofs post-mitotic characteristics adult heart. However, emerging evidence supports more dynamic view myocardium which cell death restoration are vital components remodeling process that governs homeostasis, disease. identification dividing throughout life span organisms recognition undifferentiated primitive cells regulate turnover regeneration indicate is self-renewing controlled by compartment resident stem cells. Moreover, exogenous progenitors bone marrow origin transdifferentiate acquire cardiomyocyte vascular lineages. This new reality constitutes foundation numerous cell-based clinical trials conducted last decade treatment ischemic non-ischemic cardiomyopathies.
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