Can currently available non-animal methods detect pre and pro-haptens relevant for skin sensitization?
作者： Grace Patlewicz , Silvia Casati , David A. Basketter , David Asturiol , David W. Roberts
DOI: 10.1016/J.YRTPH.2016.08.007
关键词: Sensitization 、 Skin sensitization 、 Immunology 、 Activation test 、 Hapten 、 Local lymph node assay 、 Cosmetics 、 Predictive testing 、 Medicine 、 Human cell line
摘要: … 1,2-Dibromo-2,4-dicyanobutane (MDGN) was assigned as a pre-Michael acceptor (pre-MA) or possibly a pre-S N 2 - loss of HBr could result in either a vinylic bromide that could …
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