Topical application of Moringa oleifera leaf extract ameliorates experimentally induced atopic dermatitis by the regulation of Th1/Th2/Th17 balance
作者： Eun-Ju Choi , Trishna Debnath , Yujiao Tang , Young-Bae Ryu , Sang-Ho Moon
DOI: 10.1016/J.BIOPHA.2016.09.085
关键词: Thymic stromal lymphopoietin 、 RAR-related orphan receptor gamma 、 HaCaT 、 Immunology 、 In vivo 、 Pharmacology 、 Mannose receptor 、 Lymph 、 Orphan receptor 、 Moringa 、 Medicine
摘要: Abstract Background Moringa oleifera ( M. ) is widely cultivated in tropical and subtropical regions has been used as a vegetable traditional medicine. In this study, the anti-atopic dermatitis activity of ethanol extract leaf was investigated vitro vivo. Methods For HaCaT human keratinocytes were for cytokines MAPKinase assay. vivo ethanolic (MO) topically applied to BALB/c mice with Dermatophagoides farinae (DFE; house dust mite extract)- 2,4-dinitrochlorobenzene (DNCB)-induced atopic (AD). Results The expression TNF-α, CCL17, IL-1β, IL-6 pro-inflammatory cytokine-related mRNA, mitogen-activated protein kinases (MAPKs) TNF-α/IFN-γ-induced reduced by MO. Epidermal dermal ear thickness, mast cell infiltration, serum immunoglobulin levels, well gene various tissue, lymph nodes, splenocytes improved treatment addition, MO retinoic acid-related orphan receptor γT (RORγT), thymic stromal lymphopoietin (TSLP), mannose (CD206) mRNA tissue cervical node size. Conclusion results study strongly suggest beneficial effects on AD via regulation inflammatory responses.
em-consulte.com参考文章(41)
Abdulrahman Khazim Al-Asmari, Sulaiman Mansour Albalawi, Md Tanwir Athar, Abdul Quaiyoom Khan, Hamoud Al-Shahrani, Mozaffarul Islam, Moringa oleifera as an Anti-Cancer Agent against Breast and Colorectal Cancer Cell Lines PLOS ONE. ,vol. 10, pp. e0135814- ,(2015) , 10.1371/JOURNAL.PONE.0135814
Steen Lisby, Ole Baadsgaard, Mechanisms of Irritant Contact Dermatitis Springer Berlin Heidelberg. pp. 91- 110 ,(2001) , 10.1007/978-3-662-10302-9_4
Katelynn A. Milora, Hangfei Fu, Ornella Dubaz, Liselotte E. Jensen, Unprocessed Interleukin-36α Regulates Psoriasis-Like Skin Inflammation in Cooperation With Interleukin-1. Journal of Investigative Dermatology. ,vol. 135, pp. 2992- 3000 ,(2015) , 10.1038/JID.2015.289
Kei-ichi Yamanaka, Hitoshi Mizutani, The Role of Cytokines/Chemokines in the Pathogenesis of Atopic Dermatitis Current problems in dermatology. ,vol. 41, pp. 80- 92 ,(2011) , 10.1159/000323299
T. Bieber, H.-U. Simon, Allergen-specific immunotherapy: current concepts and future directions. Allergy. ,vol. 66, pp. 709- 712 ,(2011) , 10.1111/J.1398-9995.2011.02595.X
Harald Carlsen, George Alexander, Liv M.I Austenaa, Kanae Ebihara, Rune Blomhoff, Molecular imaging of the transcription factor NF-κB, a primary regulator of stress response Mutation Research. ,vol. 551, pp. 199- 211 ,(2004) , 10.1016/J.MRFMMM.2004.02.024
Susanne Kaesler, Thomas Volz, Yuliya Skabytska, Martin Köberle, Ulrike Hein, Ko-Ming Chen, Emmanuella Guenova, Florian Wölbing, Martin Röcken, Tilo Biedermann, Toll-like Receptor 2 Ligands Promote Chronic Atopic Dermatitis Through IL-4-mediated Suppression of IL-10 The Journal of Allergy and Clinical Immunology. ,vol. 134, pp. 92- 99 ,(2014) , 10.1016/J.JACI.2014.02.017
Vassili Soumelis, Pedro A Reche, Holger Kanzler, Wei Yuan, Gina Edward, Bernhart Homey, Michel Gilliet, Steve Ho, Svetlana Antonenko, Annti Lauerma, Kathleen Smith, Daniel Gorman, Sandra Zurawski, Jon Abrams, Satish Menon, Terri McClanahan, Rene de Waal-Malefyt, Fernando Bazan, Robert A Kastelein, Yong-Jun Liu, None, Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP Nature Immunology. ,vol. 3, pp. 673- 680 ,(2002) , 10.1038/NI805
Sang-Hyun Kim, Eun-Kyung Kim, Eun-Ju Choi, High-Intensity Swimming Exercise Increases Dust Mite Extract and 1-Chloro-2,4-Dinitrobenzene-Derived Atopic Dermatitis in BALB/c Mice Inflammation. ,vol. 37, pp. 1179- 1185 ,(2014) , 10.1007/S10753-014-9843-Z
Yoshiaki Tomimori, Yoshitaka Tanaka, Megumi Goto, Yoshiaki Fukuda, Repeated topical challenge with chemical antigen elicits sustained dermatitis in NC/Nga mice in specific-pathogen-free condition. Journal of Investigative Dermatology. ,vol. 124, pp. 119- 124 ,(2005) , 10.1111/J.0022-202X.2004.23516.X